News
Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia
The major aim of this randomized treatment discontinuation trial was to test the hypothesis that smokers with schizophrenia require extended duration pharmacotherapy to prevent relapse to smoking.
Cognitive Remediation with D-cycloserine to Improve Smoking Cessation Outcomes
The major aim of this randomized clinical trial was to evaluate the effect of addition of the putative cognitive-enhancing agent, D-cycloserine, to cue exposure therapy on reactivity to smoking-related cues and relapse in recently abstinent smokers.
Effect of Mindfulness Training on Impulsivity in Smokers
Evaluation of feasibility and efficacy of Mindfulness Training (MT) in comparison to Cognitive Behavioral Therapy (CBT) for smoking cessation.
Cooperative Drug Discovery for the Treatment of Nicotine Dependence
The major aim of this study was to test two novel Phase II compounds for efficacy for treatment of nicotine dependence and to test a predictive battery of putative biomarkers for response to treatment.
Glycine Transport Inhibition for Nicotine Dependence in Schizophrenia
The major aim of this randomized clinical trial was to test the hypothesis that a single dose of propranolol given prior to smoking-related cue exposure would decrease psychophysiological responses to smoking cues one week later through a process of memory reconsolidation blockade.
Memory Reconsolidation Blockade as a Novel Intervention for Nicotine Dependence
The major aim of this randomized clinical trial was to test the hypothesis that a single dose of propranolol given prior to smoking-related cue exposure would decrease psychophysiological responses to smoking cues one week later through a process of memory reconsolidation blockade. Received Cutting Edge Basic Research Award.
Mentoring in Patient-Oriented Addiction Research
This grant is designed to develop specific content expertise in treatment and recovery policy, and the design, implementation, and evaluation of treatment and recovery support service combinations. This grant also allows for mentoring junior investigators in patient-orientated addiction research (POAR).
Recovery Research Institute (RRI)
Some of the RRI projects include building and maintaining a website in order to provide a credible source of information to debunk addiction and recovery myths, and provide free access to the latest recovery research information; building and evaluating recovery support programs in the community; building and evaluating recovery support programs in educational settings such…MORE
Smoking Cessation and Cessation Maintenance in Smokers with and without Severe Mental Illness (SMI) During Sustained Pharmacotherapy with Varenicline
This study is using a combined data set consisting of the data collected at MGH by Dr. Evins from a study population of smokers with SMI and a study with a comparable study design conducted at Pfizer in a population of smokers without SMI. The aim is to test the hypotheses that smokers without SMI…MORE
Using Functional Magnetic Resonance Imaging to Characterize Cigarette Smoking in Neurocognitive Domains
The purpose of this study is to characterize the structural and functional brain circuitry of smokers in order to gain a better understanding of the neuroscience underlying nicotine addiction. Specifically, we use neuroimaging to characterize smokers in 3 domains; cue reactivity, sustained attention, and inhibitory control; as well as asses resting brain function.