Center for Addiction Medicine

Active Studies

MGH Ceneter for Addiction Medicine researchersThe work of the Center is carried out through clinical trials that investigate causes of substance use disorders and investigate novel treatments. These findings in these studies often affect the way treatment is delivered in actual healthcare environments. Information about the studies currently being conducted may be accessed through the list below.

For more information on previous research, visit the Past Studies page.

 

Marijuana Smokers

Effect of Medical Marijuana on Neurocognition and Escalation of Use [Details]

Principal Investigator(s): Jodi Gilman , 2016—2020
Study Reference: 5K01DA034093

The purpose of this study is to evaluate the the effect of medical marijuana (MM) on a range of outcomes, including clinical symptoms, cognitive performance, brain function, and possible transition to cannabis use disorders (CUD), in adults who are interested in using medical marijuana to treat pain, insomnia, depression, or anxiety. We will conduct longitudal assessments over 6 months that will: (1) characterize the impact of MM on progression to CUD, as well as other indices of addiction such as increased tolerance and withdrawal among those who stop using MM, (2) assess, via daily dosing diaries, the effect of MM use patterns on use of other medications and perception of underlying disease symptomatology, (3) characterize the impact of MM on neurocognitive performance, including executive function, memory, attention, and decision-making and (4) examine evidence for impact of MM on brain function in the prefrontal cortex and reward regions.

Web-based Survey of Individuals Interested in Using Medical Marijuana [Details]

Principal Investigator(s): Gilman, 2015—2020
Study Reference: NIH/NIDA 1K01DA034093-01A

The aims of this study are to characterize the most common illnesses for which MM is sought, the reasons for seeking MM, reasons for hesitance to use and to characterize current marijuana use habits of those interested in using MM.

Cognition and Adolescent Health [Details]

Principal Investigator(s): Schuster, Gilman, Evins, 2015—2020
Study Reference: 5K01DA034093-03

The purpose of this study is to provide updated information on prevalence and frequency of cannabis use in relation to other forms of substance use in a representative sample of high-school aged adolescents, to evaluate the effect of contingency management on initial 30-day verified cannabis abstinence in adolescents and older adolescents who use cannabis at least weekly and are not seeking treatment, to determine whether there is cognitive dysfunction in cannabis use that persists in the short term (4 days) after use but resolves with extended abstinence (30 days) compared to cannabis users who do not quit and non-using controls and to estimate the rate of cognitive improvement with cannabis abstinence as a function of time since last use and concentration of detectable cannabis metabolites in urine.

Mentoring in Patient-Oriented Addiction Research [Details]

Principal Investigator(s): Kelly, 2014—2019
Study Reference: National Institute of Alcohol Abuse and Alcoholism/K24AA022136-01

This grant is designed to develop specific content expertise in treatment and recovery policy, and the design, implementation, and evaluation of treatment and recovery support service combinations. This grant also allows for mentoring junior investigators in patient-orientated addiction research (POAR).

Examining the Effectiveness of a Peer-support Model for Parents and Caregivers of Addicted Loved Ones [Details]

Principal Investigator(s): Kelly, 2014—2105
Study Reference: Recovery Research Institute (RRI)

This study aims to assess the subjective benefits of participation in face-to-face meetings for both Learn to Cope affiliates and their family members with addiction problems; to examine the extent to which Learn to Cope is associated with improving its members’ understanding of and competence in dealing with their loved ones’ addiction as well as helping their loved ones’ chances of recovery from addiction.

Using Imaging to Assess Effects of THC on Brain Activity [Details]

Principal Investigator(s): Gilman, 2013—2017
Study Reference: NIDA 1K01DA034093

The aim of this study is to assess the effects of THC intoxication using the medication dronabinol (synthetic THC) on resting state and task-based activation in the prefrontal cortex (PFC), as well as on neurocognitive task performance and correlations between these measurements and clinical signs of intoxication, as well as to investigate at which doses of dronabinol an effect on neurocognitive task performance or an effect on PFC activity can be observed.

Recovery Research Institute (RRI) [Details]

Principal Investigator(s): Kelly, 2011—2019
Study Reference: Tower Foundation and private donors

Some of the RRI projects include building and maintaining a website in order to provide a credible source of information to debunk addiction and recovery myths, and provide free access to the latest recovery research information; building and evaluating recovery support programs in the community; building and evaluating recovery support programs in educational settings such as high schools and colleges; understanding the impact of community mutual-help organizations; addiction treatment system program evaluation.

Tobacco Smokers

Integrated Smoking Cessation Treatment for Smokers with Serious Mental Illnesses [Details]

Principal Investigator(s): A. Eden Evins, M.D., M.P.H., 2016—2021
Study Reference: PCORI 1504-30472

The aim of this study is to study the effectiveness of two practical approaches to improve the health of people with mental illness in the community. The project will test whether tailored education to primary care doctors alone or combined with community health workers will help those with mental illness quit smoking. More than 1,100 patients at 50 Boston area community health clinics will be involved. Bay Cove Human Services and Vinfen, two of the largest mental health service providers in the Commonwealth, will lead the clinical component of this study.

Mentoring in Patient-Oriented Addiction Research [Details]

Principal Investigator(s): Kelly, 2014—2019
Study Reference: National Institute of Alcohol Abuse and Alcoholism/K24AA022136-01

This grant is designed to develop specific content expertise in treatment and recovery policy, and the design, implementation, and evaluation of treatment and recovery support service combinations. This grant also allows for mentoring junior investigators in patient-orientated addiction research (POAR).

Examining the Effectiveness of a Peer-support Model for Parents and Caregivers of Addicted Loved Ones [Details]

Principal Investigator(s): Kelly, 2014—2105
Study Reference: Recovery Research Institute (RRI)

This study aims to assess the subjective benefits of participation in face-to-face meetings for both Learn to Cope affiliates and their family members with addiction problems; to examine the extent to which Learn to Cope is associated with improving its members’ understanding of and competence in dealing with their loved ones’ addiction as well as helping their loved ones’ chances of recovery from addiction.

Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety Disorders [Details]

Principal Investigator(s): Evins, 2013—2018
Study Reference: P50 DA 036107-01

The aim of this study is to assess the effect of switching to gradually reduced nicotine content cigarettes on product use patterns and biomarkers of exposure, on psychiatric and nicotine withdrawal symptoms and on self-perception of tobacco dependence, self-report of intention to quit smoking, and actual smoking cessation attempts in smokers with mood and/or anxiety disorders.

Landing pages:
http://boston.craigslist.org/gbs/vol/5275723869.html
http://boston.craigslist.org/bmw/vol/5265708831.html

More information at ClinicalTrials.gov.

Using Functional Magnetic Resonance Imaging to Characterize Cigarette Smoking in Neurocognitive Domains [Details]

Principal Investigator(s): Gilman, 2013—2106
Study Reference: IH K24DA030443-04

The purpose of this study is to characterize the structural and functional brain circuitry of smokers in order to gain a better understanding of the neuroscience underlying nicotine addiction. Specifically, we use neuroimaging to characterize smokers in 3 domains; cue reactivity, sustained attention, and inhibitory control; as well as asses resting brain function.

Subway ad for Using Functional Magnetic Resonance Imaging to Characterize Cigarette Smoking in Neurocognitive Domains Study

 

 

Recovery Research Institute (RRI) [Details]

Principal Investigator(s): Kelly, 2011—2019
Study Reference: Tower Foundation and private donors

Some of the RRI projects include building and maintaining a website in order to provide a credible source of information to debunk addiction and recovery myths, and provide free access to the latest recovery research information; building and evaluating recovery support programs in the community; building and evaluating recovery support programs in educational settings such as high schools and colleges; understanding the impact of community mutual-help organizations; addiction treatment system program evaluation.

Alcohol and Mixed Drug Use

Mentoring in Patient-Oriented Addiction Research [Details]

Principal Investigator(s): Kelly, 2014—2019
Study Reference: National Institute of Alcohol Abuse and Alcoholism/K24AA022136-01

This grant is designed to develop specific content expertise in treatment and recovery policy, and the design, implementation, and evaluation of treatment and recovery support service combinations. This grant also allows for mentoring junior investigators in patient-orientated addiction research (POAR).

Examining the Effectiveness of a Peer-support Model for Parents and Caregivers of Addicted Loved Ones [Details]

Principal Investigator(s): Kelly, 2014—2105
Study Reference: Recovery Research Institute (RRI)

This study aims to assess the subjective benefits of participation in face-to-face meetings for both Learn to Cope affiliates and their family members with addiction problems; to examine the extent to which Learn to Cope is associated with improving its members’ understanding of and competence in dealing with their loved ones’ addiction as well as helping their loved ones’ chances of recovery from addiction.

Recovery Research Institute (RRI) [Details]

Principal Investigator(s): Kelly, 2011—2019
Study Reference: Tower Foundation and private donors

Some of the RRI projects include building and maintaining a website in order to provide a credible source of information to debunk addiction and recovery myths, and provide free access to the latest recovery research information; building and evaluating recovery support programs in the community; building and evaluating recovery support programs in educational settings such as high schools and colleges; understanding the impact of community mutual-help organizations; addiction treatment system program evaluation.

Depression and Other Mental Health Conditions

Integrated Smoking Cessation Treatment for Smokers with Serious Mental Illnesses [Details]

Principal Investigator(s): A. Eden Evins, M.D., M.P.H., 2016—2021
Study Reference: PCORI 1504-30472

The aim of this study is to study the effectiveness of two practical approaches to improve the health of people with mental illness in the community. The project will test whether tailored education to primary care doctors alone or combined with community health workers will help those with mental illness quit smoking. More than 1,100 patients at 50 Boston area community health clinics will be involved. Bay Cove Human Services and Vinfen, two of the largest mental health service providers in the Commonwealth, will lead the clinical component of this study.

Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety Disorders [Details]

Principal Investigator(s): Evins, 2013—2018
Study Reference: P50 DA 036107-01

The aim of this study is to assess the effect of switching to gradually reduced nicotine content cigarettes on product use patterns and biomarkers of exposure, on psychiatric and nicotine withdrawal symptoms and on self-perception of tobacco dependence, self-report of intention to quit smoking, and actual smoking cessation attempts in smokers with mood and/or anxiety disorders.

Landing pages:
http://boston.craigslist.org/gbs/vol/5275723869.html
http://boston.craigslist.org/bmw/vol/5265708831.html

More information at ClinicalTrials.gov.