Center for Addiction Medicine


Integrated Behavioral Diabetes Management for Individuals with Serious Mental Illness

The goal of this project was to improve health outcomes for people with serious mental illness (SMI) and diabetes, a highly prevalent comorbidity that results in high levels of healthcare utilization and poor medical outcomes, including significant premature mortality. We developed a 16-week tailored behavioral and educational group intervention for individuals with schizophrenia and diabetes, utilizing…MORE

Integrated Smoking Cessation Treatment for Smokers with Serious Mental Illnesses

The aim of this study is to study the effectiveness of two practical approaches to improve the health of people with mental illness in the community. The project will test whether tailored education to primary care doctors alone or combined with community health workers will help those with mental illness quit smoking. More than 1,100…MORE

Optimizing Real-time fMRI for Neurotherapeutic Discovery and Development

This grant provided funding to hold an Exploratory Seminar at the Radcliffe Institute for Advanced Study to bring 18 scientists together from across the US for a two-day meeting with the aim of advancing development of real-time fMRI as a neurotherapeutic tool with applications to addictive disorders, obsessive-compulsive disorder, major depressive disorder, post-traumatic stress disorder,…MORE

Extended Duration Varenicline for prevention of Relapse to Smoking in Patients with Schizophrenia

This investigator-initiated study provides study medication and additional funding to supplement NIDA R01 DA021245 ‘Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia’ to evaluate safety and efficacy of varenicline in smokers with schizophrenia.

Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia

The major aim of this randomized treatment discontinuation trial was to test the hypothesis that smokers with schizophrenia require extended duration pharmacotherapy to prevent relapse to smoking.

Glycine Transport Inhibition for Nicotine Dependence in Schizophrenia

The major aim of this randomized clinical trial was to test the hypothesis that a single dose of propranolol given prior to smoking-related cue exposure would decrease psychophysiological responses to smoking cues one week later through a process of memory reconsolidation blockade.

Enhancing Outcomes, Reducing Costs: Evaluating Peer Support for Mood Disorder

This study will characterize Depression and Bipolar Support Alliance (DBSA) participants and their participation in the organization; and, obtain preliminary estimates of the organizations’ purported clinical and recovery utility. More information at

Smoking Cessation and Cessation Maintenance in Smokers with and without Severe Mental Illness (SMI) During Sustained Pharmacotherapy with Varenicline

This study is using a combined data set consisting of the data collected at MGH by Dr. Evins from a study population of smokers with SMI and a study with a comparable study design conducted at Pfizer in a population of smokers without SMI. The aim is to test the hypotheses that smokers without SMI…MORE

Decision-Making and Drug Use

The aim of the study is to design novel behavioral tasks that will allow us to separate and empirically measure factors that predict social influence. We would like to design new tasks based on classic psychological studies that will allows us to model social influence, to observe differences between non-dependent young adults aged 18-25 who…MORE

Neurobehavioral Predictors of Weight-Loss Surgery Outcomes

The major aim of this project is to begin to characterize neurobehavioral similarities and differences in certain phenotypes of obesity and addictive substance use disorders.